CREB3L4

Across TCGA pan-cancer cohorts, CREB3L4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CREB3L4 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CREB3L4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CREB3L4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where CREB3L4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	1.000	0.835	.012	32	view →
HNSC	DFS	Tertile	III,IV	0.520	0.987	.006	15	view →
LSCC	DFS	Quartile	All	1.000	0.516	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CREB3L4–UCEC (OS)

Open the UCEC breakdown →