CREB3L4

Across TCGA cell cohorts, CREB3L4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CREB3L4-associated genes across cancer lineages are REG1B, OR10W1, and IQCF5. Each is linked with CREB3L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB3L4-to-partner and partner-to-CREB3L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by CREB3L4-low versus CREB3L4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3L4→partner) and Y-score (partner→CREB3L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.073	+3.196	.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	KCNK4 →	+0.038	+3.708	.009	.004	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

REG1B by CREB3L4 expression — LARGE_INTESTINE

Explore this box plot interactively →