CREB3L1

Across TCGA patient cohorts, CREB3L1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREB3L1-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and PARP_cleaved. Each is linked with CREB3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB3L1-to-partner and partner-to-CREB3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CREB3L1-low versus CREB3L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3L1→partner) and Y-score (partner→CREB3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.823	+3.019	.008	.019	3	2
UCEC	Notch1 →	+0.214	+2.820	.003	.035	3	1
COAD	PARP_cleaved →	+0.552	+2.820	.036	.035	3	1
COAD	ASNS →	+0.677	+3.178	<.001	.010	3	1
UCEC	Chk2 →	-0.295	-3.321	.016	.010	2	1
UCEC	VHL →	-1.139	-3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Caspase-7-cleavedD198 by CREB3L1 expression — UCEC

Explore this box plot interactively →