CREB3L1

Across TCGA cell cohorts, CREB3L1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CREB3L1-associated genes across cancer lineages are PPP1R17, HSFY2, and GSG1L2. Each is linked with CREB3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB3L1-to-partner and partner-to-CREB3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R17 grouped by CREB3L1-low versus CREB3L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3L1→partner) and Y-score (partner→CREB3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R17 →	+0.045	+4.882	.004	<.001	3	1
LARGE_INTESTINE	HSFY2 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
SKIN	OR1L3 →	+0.014	+4.415	.001	.007	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PPP1R17 by CREB3L1 expression — LARGE_INTESTINE

Explore this box plot interactively →