CREB3

Across TCGA patient cohorts, CREB3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREB3-associated genes across cancer lineages are Rictor_pT1135, EGFR_pY1068, and eIF4E. Each is linked with CREB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB3-to-partner and partner-to-CREB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by CREB3-low versus CREB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3→partner) and Y-score (partner→CREB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.135	-3.321	.011	.010	3	2
UCEC	EGFR_pY1068 →	-0.312	-3.321	.017	.010	3	1
UCEC	eIF4E →	+0.232	+3.000	.035	.036	2	2
UCEC	Heregulin →	-0.179	-3.000	.005	.036	3	1
UCEC	INPP4B →	-0.344	-3.000	.042	.036	3	1
UCEC	Ku80 →	+0.308	+3.335	.012	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Rictor_pT1135 by CREB3 expression — UCEC

Explore this box plot interactively →