CREB3

Across TCGA cell cohorts, CREB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,111 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CREB3-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, Latent virus replication, and Release from viral latency. Each is linked with CREB3 in more than 15 cancer types. Because this analysis shows association rather than direction, both CREB3-to-partner and partner-to-CREB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway grouped by CREB3-low versus CREB3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3→partner) and Y-score (partner→CREB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.204	+1.045	<.001	<.001	3	16
BLOOD_Lymphoma	Latent virus replication →	+0.206	+0.719	<.001	<.001	3	14
BLOOD_Lymphoma	Release from viral latency →	+0.206	+0.719	<.001	<.001	3	14
STOMACH	Protein localization to endoplasmic reticulum →	+0.141	+1.311	<.001	<.001	3	14
BONE	Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.150	+0.837	<.001	<.001	3	14
BLOOD_Myeloma	Endoplasmic reticulum to cytosol transport →	+0.128	+0.879	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,111 associations by consensus.

Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway by CREB3 expression — BONE

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