CREB3

Across TCGA cell cohorts, CREB3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CREB3-associated genes across cancer lineages are OR6Q1 and LRRC3B. Each is linked with CREB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB3-to-partner and partner-to-CREB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6Q1 grouped by CREB3-low versus CREB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3→partner) and Y-score (partner→CREB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1
SKIN	LRRC3B →	+0.062	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR6Q1 by CREB3 expression — LARGE_INTESTINE

Explore this box plot interactively →