CREB3

Across TCGA cell cohorts, CREB3 mutation is significantly associated with the mutation status of many other genes, with 985 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CREB3-associated genes across cancer lineages are APBA1, KSR2, and GTF2IRD1. Each is linked with CREB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CREB3-to-partner and partner-to-CREB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APBA1 grouped by CREB3-low versus CREB3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3→partner) and Y-score (partner→CREB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APBA1 →	+2.894	+4.432	.005	.005	1	3
BLOOD_Leukemia	KSR2 →	+3.157	+4.665	.003	.003	1	3
BLOOD_Leukemia	GTF2IRD1 →	+3.672	+5.083	.001	.001	1	3
BLOOD_Leukemia	TNS1 →	+2.894	+4.432	.005	.005	1	3
SKIN	TBR1 →	+5.053	+4.239	.007	.007	1	3
SKIN	ERC2 →	+2.593	+4.282	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 985 associations by consensus.

APBA1 by CREB3 expression — BLOOD_Leukemia

Explore this box plot interactively →