CRCT1

Across TCGA patient cohorts, CRCT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,787 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CRCT1-associated GO terms across cancer lineages are Keratinization, Positive regulation of epidermis development, and Skin epidermis development. Each is linked with CRCT1 in more than 13 cancer types. Because this analysis shows association rather than direction, both CRCT1-to-partner and partner-to-CRCT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Keratinization grouped by CRCT1-low versus CRCT1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRCT1→partner) and Y-score (partner→CRCT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Keratinization →	+0.281	+5.420	<.001	<.001	3	14
ESCA	Positive regulation of epidermis development →	+0.057	+2.686	<.001	<.001	3	13
ESCA	Skin epidermis development →	+0.053	+2.818	<.001	<.001	3	12
ESCA	Establishment of skin barrier →	+0.094	+3.319	<.001	<.001	3	12
ESCA	Regulation of epidermis development →	+0.073	+3.733	<.001	<.001	3	12
ESCA	Epidermal cell differentiation →	+0.085	+4.721	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,787 associations by consensus.

Keratinization by CRCT1 expression — ESCA

Explore this box plot interactively →