CRCP

Across TCGA patient cohorts, CRCP mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRCP-associated genes across cancer lineages are MRPS5P3, OFD1P3Y, and LINC02520. Each is linked with CRCP in more than 1 cancer types. Because this analysis shows association rather than direction, both CRCP-to-partner and partner-to-CRCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS5P3 grouped by CRCP-low versus CRCP-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRCP→partner) and Y-score (partner→CRCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MRPS5P3 →	+0.256	+5.070	.003	.001	3	1
LUSC	OFD1P3Y →	+0.102	+4.548	<.001	.009	3	1
UCEC	LINC02520 →	+0.315	+3.279	<.001	.002	3	1
UCEC	PDCL2P1 →	+0.190	+3.747	.001	.003	3	1
COAD	RNU6-819P →	+0.427	+7.741	<.001	.009	3	1
UCEC	MIR98 →	+0.547	+3.801	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MRPS5P3 by CRCP expression — LUSC

Explore this box plot interactively →