CRB3

Across TCGA pan-cancer cohorts, CRB3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CRB3 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CRB3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CRB3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where CRB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.937	0.561	.015	9	view →
CCRCC	DFS	Median	IV	0.164	0.861	.038	6	view →
LUAD	DFS	Median	All	0.716	0.950	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CRB3–LSCC (DFS)

Open the LSCC breakdown →