CRB3

Across TCGA patient cohorts, CRB3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRB3-associated genes across cancer lineages are PDCD4, AMPK_alpha, and MEK1. Each is linked with CRB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRB3-to-partner and partner-to-CRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CRB3-low versus CRB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRB3→partner) and Y-score (partner→CRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.809	-3.000	.002	.037	3	1
UCEC	AMPK_alpha →	-0.220	-3.000	.046	.037	3	1
UCEC	MEK1 →	+0.668	+3.000	.001	.037	2	1
UCEC	mTOR_pS2448 →	-0.182	-3.000	.034	.037	2	1
UCEC	mTOR →	-0.305	-3.000	.001	.037	1	1
UCEC	TFRC →	+0.684	+3.000	.025	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PDCD4 by CRB3 expression — UCEC

Explore this box plot interactively →