CRB1

Across TCGA patient cohorts, CRB1 mutation is significantly associated with the RNA expression of many other genes, with 7,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRB1-associated genes across cancer lineages are RFC5, CACYBP, and CHEK1. Each is linked with CRB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CRB1-to-partner and partner-to-CRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC5 grouped by CRB1-low versus CRB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRB1→partner) and Y-score (partner→CRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC5 →	+0.386	+1.116	<.001	.008	3	5
LUSC	CACYBP →	+0.350	+1.452	<.001	<.001	3	5
UCEC	CHEK1 →	+0.514	+1.658	<.001	<.001	3	5
UCEC	DNAJC9 →	+0.365	+1.737	.003	.001	3	5
UCEC	MCM6 →	+0.480	+1.584	<.001	.001	3	5
UCEC	OIP5 →	+0.652	+1.699	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,138 associations by consensus.

RFC5 by CRB1 expression — LUAD

Explore this box plot interactively →