CRB1

Across TCGA cell cohorts, CRB1 mutation is significantly associated with the RNA expression of many other genes, with 386 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRB1-associated genes across cancer lineages are MRPL16, OCSTAMP, and POU1F1. Each is linked with CRB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRB1-to-partner and partner-to-CRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL16 grouped by CRB1-low versus CRB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRB1→partner) and Y-score (partner→CRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MRPL16 →	+0.355	+3.949	.009	<.001	3	2
LUNG_NSCLC_LUAD	OCSTAMP →	+0.007	+2.343	.001	.003	3	2
LUNG_NSCLC_LUAD	POU1F1 →	+0.022	+2.214	.006	.007	3	2
LARGE_INTESTINE	SLC17A5 →	+0.643	+2.628	.005	.002	3	2
LARGE_INTESTINE	EREG →	+1.933	+2.628	.005	.002	3	2
LARGE_INTESTINE	GPR108 →	+0.462	+3.321	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 386 associations by consensus.

MRPL16 by CRB1 expression — SKIN

Explore this box plot interactively →