CRAT

Across TCGA patient cohorts, CRAT mutation is significantly associated with the RNA expression of many other genes, with 1,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRAT-associated genes across cancer lineages are NDUFAF4, RN7SL96P, and MIR6870. Each is linked with CRAT in more than 2 cancer types. Because this analysis shows association rather than direction, both CRAT-to-partner and partner-to-CRAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF4 grouped by CRAT-low versus CRAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRAT→partner) and Y-score (partner→CRAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF4 →	+0.603	+3.353	.001	.005	3	3
BRCA	RN7SL96P →	+0.146	+3.975	<.001	.005	3	2
BLCA	MIR6870 →	+0.732	+2.589	.002	.009	3	2
UCEC	ERVE-1 →	+0.656	+2.748	<.001	.003	3	2
UCEC	MIA-RAB4B →	+0.083	+2.152	<.001	<.001	3	2
SKCM	SNRPFP4 →	+0.214	+2.854	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,958 associations by consensus.

NDUFAF4 by CRAT expression — UCEC

Explore this box plot interactively →