CRAT

Across TCGA cell cohorts, CRAT mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRAT-associated genes across cancer lineages are AGTR2, OR5P2, and TRH. Each is linked with CRAT in more than 1 cancer types. Because this analysis shows association rather than direction, both CRAT-to-partner and partner-to-CRAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGTR2 grouped by CRAT-low versus CRAT-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRAT→partner) and Y-score (partner→CRAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AGTR2 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR5P2 →	+0.028	+4.867	<.001	.009	3	1
STOMACH	TRH →	+0.065	+3.632	<.001	.009	3	1
STOMACH	HTR3C →	+0.053	+3.632	<.001	.009	3	1
STOMACH	CEACAM18 →	+0.404	+3.637	.008	.008	3	1
LARGE_INTESTINE	FZD3 →	+0.705	+3.237	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

AGTR2 by CRAT expression — BLOOD_Lymphoma

Explore this box plot interactively →