CRAMP1

Across TCGA patient cohorts, CRAMP1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRAMP1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and FOXO3a_pS318_S321. Each is linked with CRAMP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRAMP1-to-partner and partner-to-CRAMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CRAMP1-low versus CRAMP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRAMP1→partner) and Y-score (partner→CRAMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.780	+2.019	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.524	+2.415	.002	.003	3	3
UCEC	FOXO3a_pS318_S321 →	-0.089	-1.382	.021	.017	3	2
UCEC	PCNA →	+0.193	+1.736	.003	.006	3	2
UCEC	Stathmin →	+0.113	+1.201	.007	.028	3	2
UCEC	ATM →	-0.565	-3.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by CRAMP1 expression — UCEC

Explore this box plot interactively →