CRACR2A

Across TCGA patient cohorts, CRACR2A mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRACR2A-associated genes across cancer lineages are eEF2, Src_pY527, and ETS-1. Each is linked with CRACR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CRACR2A-to-partner and partner-to-CRACR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CRACR2A-low versus CRACR2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACR2A→partner) and Y-score (partner→CRACR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.346	+2.321	.002	.005	3	2
UCEC	Src_pY527 →	-0.342	-1.430	.011	.022	3	2
LUSC	ETS-1 →	+0.206	+2.816	.010	.036	3	1
LUSC	PEA-15 →	+0.287	+2.816	.027	.036	3	1
UCEC	EGFR_pY1068 →	-0.299	-2.584	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.148	-2.000	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

eEF2 by CRACR2A expression — UCEC

Explore this box plot interactively →