Across TCGA patient cohorts, CRACDL mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRACDL-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Notch1. Each is linked with CRACDL in more than 1 cancer types. Because this analysis shows association rather than direction, both CRACDL-to-partner and partner-to-CRACDL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACDL→partner) and Y-score (partner→CRACDL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.308	-3.807	<.001	<.001	3	2
UCEC	MEK1 →	+0.335	+1.807	.007	.004	3	2
UCEC	Notch1 →	+0.113	+1.495	.018	.034	3	2
UCEC	p62 Lck ligand →	+0.385	+2.331	<.001	.003	3	2
UCEC	ATM →	-0.343	-2.308	.026	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.627	+1.697	.001	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

CRACDL survival (RNA) · tumor vs normal (RNA) · all CRACDL data types