CRACD

Across TCGA pan-cancer cohorts, CRACD mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CRACD’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CRACD mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CRACD is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, PDAC, and COAD are the cancer types where CRACD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRACD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	−0.524	<.001	9	view →
PDAC	Female	All	+0.663	<.001	8	view →
COAD	Female	II,III,IV	−0.304	<.001	7	view →
LUAD	Male	All	+0.258	<.001	5	view →
HNSC	All	All	+0.478	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CRACD–CCRCC

Open the CCRCC breakdown →