CRACD

Across TCGA patient cohorts, CRACD mutation is significantly associated with the RNA expression of many other genes, with 6,643 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRACD-associated genes across cancer lineages are ACTG1P12, THRB, and SASS6. Each is linked with CRACD in more than 4 cancer types. Because this analysis shows association rather than direction, both CRACD-to-partner and partner-to-CRACD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTG1P12 grouped by CRACD-low versus CRACD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACD→partner) and Y-score (partner→CRACD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACTG1P12 →	+0.129	+2.007	.004	.002	3	5
LUAD	THRB →	-0.686	-2.889	<.001	.001	3	4
UCEC	SASS6 →	+0.388	+2.131	.001	<.001	3	4
UCEC	CCNB2 →	+0.726	+2.256	<.001	<.001	3	4
UCEC	ATAD3B →	+0.299	+1.657	.002	<.001	3	4
UCEC	MRPS18C →	+0.409	+1.758	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,643 associations by consensus.

ACTG1P12 by CRACD expression — SKCM

Explore this box plot interactively →