CRACD

Across TCGA cell cohorts, CRACD RNA expression is significantly associated with the go_rna of many other GO terms, with 5,356 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CRACD-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of double-strand break repair, and Regulation of barbed-end actin filament capping. Each is linked with CRACD in more than 12 cancer types. Because this analysis shows association rather than direction, both CRACD-to-partner and partner-to-CRACD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by CRACD-low versus CRACD-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACD→partner) and Y-score (partner→CRACD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of DNA repair →	+0.090	+2.146	<.001	<.001	3	13
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.086	+1.533	<.001	<.001	3	12
LIVER	Regulation of barbed-end actin filament capping →	-0.180	-1.842	<.001	<.001	3	12
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.075	+1.790	<.001	<.001	3	12
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.076	+1.834	<.001	<.001	3	12
SOFT_TISSUE	Protein activation cascade →	-0.279	-1.353	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,356 associations by consensus.

Positive regulation of DNA repair by CRACD expression — LIVER

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