CRACD

Across TCGA cell cohorts, CRACD mutation is significantly associated with the RNA expression of many other genes, with 1,266 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRACD-associated genes across cancer lineages are CBX2, SHISA6, and ZNF684. Each is linked with CRACD in more than 3 cancer types. Because this analysis shows association rather than direction, both CRACD-to-partner and partner-to-CRACD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX2 grouped by CRACD-low versus CRACD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACD→partner) and Y-score (partner→CRACD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBX2 →	+0.878	+2.459	.001	.006	3	4
BLOOD_Lymphoma	SHISA6 →	+0.008	+3.209	<.001	.004	3	3
LUNG_SCLC	ZNF684 →	+1.188	+3.321	<.001	.002	3	3
LARGE_INTESTINE	PCNT →	+0.651	+2.158	.003	.004	3	3
LUNG_SCLC	ZFP69B →	+1.142	+2.584	.003	.003	3	3
LARGE_INTESTINE	DFFA →	+0.606	+2.850	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,266 associations by consensus.

CBX2 by CRACD expression — LARGE_INTESTINE

Explore this box plot interactively →