CRACD

Across TCGA cell cohorts, CRACD mutation is significantly associated with the mutation status of many other genes, with 4,719 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRACD-associated genes across cancer lineages are FAT4, SYNE2, and CDK13. Each is linked with CRACD in more than 5 cancer types. Because this analysis shows association rather than direction, both CRACD-to-partner and partner-to-CRACD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAT4 grouped by CRACD-low versus CRACD-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACD→partner) and Y-score (partner→CRACD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FAT4 →	+2.204	+2.791	.005	.005	1	6
BLOOD_Leukemia	SYNE2 →	+1.625	+2.217	.001	.001	1	6
LARGE_INTESTINE	CDK13 →	+2.700	+3.493	<.001	<.001	1	6
OVARY	ITGB4 →	+3.619	+3.619	<.001	<.001	1	6
OVARY	KMT2B →	+2.882	+3.781	<.001	<.001	1	6
CNS	NRP2 →	+4.614	+4.614	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,719 associations by consensus.

FAT4 by CRACD expression — OVARY

Explore this box plot interactively →