CRABP2

Across TCGA patient cohorts, CRABP2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRABP2-associated genes across cancer lineages are EGFR, Ku80, and PKC-delta_pS664. Each is linked with CRABP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRABP2-to-partner and partner-to-CRABP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by CRABP2-low versus CRABP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRABP2→partner) and Y-score (partner→CRABP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.290	-3.584	<.001	.002	3	1
UCEC	Ku80 →	+0.320	+2.472	.005	.011	3	1
UCEC	PKC-delta_pS664 →	-0.155	-3.584	.007	.002	3	1
UCEC	PRAS40_pT246 →	+0.177	+2.472	.032	.011	3	1
UCEC	Rab25 →	-0.537	-3.584	<.001	.002	3	1
UCEC	Rictor_pT1135 →	-0.098	-3.000	.048	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR by CRABP2 expression — UCEC

Explore this box plot interactively →