Across TCGA patient cohorts, CR1 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CR1-associated genes across cancer lineages are Cyclin-B1, HER2, and ACC1. Each is linked with CR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CR1-to-partner and partner-to-CR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CR1→partner) and Y-score (partner→CR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.597	+4.169	<.001	<.001	3	4
HNSC	HER2 →	+1.043	+3.000	<.001	.035	3	3
LIHC	ACC1 →	+0.521	+3.016	.013	.018	3	3
UCEC	eIF4E →	+0.163	+1.502	.003	<.001	3	3
UCEC	MEK1 →	+0.393	+1.502	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.255	+1.444	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Exploration

CR1 survival (RNA) · tumor vs normal (RNA) · all CR1 data types