Across TCGA cell cohorts, CR1 mutation is significantly associated with the RNA expression of many other genes, with 453 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CR1-associated genes across cancer lineages are GSG1L, ZNF99, and BOD1L2. Each is linked with CR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CR1-to-partner and partner-to-CR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CR1→partner) and Y-score (partner→CR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GSG1L →	+0.051	+3.584	<.001	.006	3	2
LIVER	ZNF99 →	+0.157	+3.584	.001	.006	3	2
LIVER	BOD1L2 →	+0.006	+3.459	<.001	.004	3	2
BLOOD_Leukemia	CCDC42 →	+0.328	+3.615	<.001	.004	3	2
LUNG_SCLC	AMY1A →	+0.246	+3.256	.001	.005	3	2
CNS	PNMA6E →	+0.352	+4.129	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 453 associations by consensus.

Exploration

CR1 survival (RNA) · tumor vs normal (RNA) · all CR1 data types