CPVL

Across TCGA patient cohorts, CPVL mutation is significantly associated with the RNA expression of many other genes, with 621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPVL-associated genes across cancer lineages are SKA1, CXCL10, and RAD51. Each is linked with CPVL in more than 1 cancer types. Because this analysis shows association rather than direction, both CPVL-to-partner and partner-to-CPVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by CPVL-low versus CPVL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPVL→partner) and Y-score (partner→CPVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.624	+3.346	.004	.005	3	2
UCEC	CXCL10 →	+1.247	+2.436	.005	.002	3	2
UCEC	RAD51 →	+0.717	+4.180	.001	<.001	3	2
UCEC	LAG3 →	+1.156	+3.087	<.001	<.001	3	2
SKCM	RN7SL460P →	+0.098	+3.594	<.001	.003	3	2
SKCM	MIR3689B →	+0.148	+4.411	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 621 associations by consensus.

SKA1 by CPVL expression — UCEC

Explore this box plot interactively →