CPVL

Across TCGA patient cohorts, CPVL mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPVL-associated genes across cancer lineages are eIF4E, JNK2, and MSH2. Each is linked with CPVL in more than 1 cancer types. Because this analysis shows association rather than direction, both CPVL-to-partner and partner-to-CPVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CPVL-low versus CPVL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPVL→partner) and Y-score (partner→CPVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+4.000	.019	<.001	3	1
UCEC	JNK2 →	+0.227	+2.906	.007	.001	3	1
UCEC	MSH2 →	-0.264	-1.700	.007	.044	3	1
UCEC	Notch1 →	+0.134	+1.700	.025	.044	3	1
UCEC	p62 Lck ligand →	+0.363	+2.906	.008	.001	3	1
UCEC	PDCD4 →	-0.433	-2.999	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4E by CPVL expression — UCEC

Explore this box plot interactively →