CPT1A

Across TCGA patient cohorts, CPT1A mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPT1A-associated genes across cancer lineages are Cyclin-B1, PDCD4, and Bid. Each is linked with CPT1A in more than 2 cancer types. Because this analysis shows association rather than direction, both CPT1A-to-partner and partner-to-CPT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CPT1A-low versus CPT1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPT1A→partner) and Y-score (partner→CPT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.658	+3.087	<.001	<.001	3	3
COAD	PDCD4 →	-0.366	-2.450	.045	.020	3	2
COAD	Bid →	+0.111	+2.841	.024	.033	3	2
COAD	Caspase-7-cleavedD198 →	+0.969	+1.753	.004	.047	3	2
UCEC	FoxM1 →	+0.175	+2.000	.031	.029	3	2
UCEC	Gab2 →	+0.258	+2.115	.022	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Cyclin-B1 by CPT1A expression — UCEC

Explore this box plot interactively →