CPSF6

Across TCGA patient cohorts, CPSF6 protein abundance is significantly associated with the RNA expression of many other genes, with 17,755 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CPSF6-associated genes across cancer lineages are RFC5, ABLIM3, and CLK2. Each is linked with CPSF6 in more than 6 cancer types. Because this analysis shows association rather than direction, both CPSF6-to-partner and partner-to-CPSF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CPSF6 versus RFC5 in LSCC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF6→partner) and Y-score (partner→CPSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC5 →	+0.719	+0.189	<.001	<.001	3	7
GBM	ABLIM3 →	-0.845	-0.291	<.001	<.001	3	7
BRCA	CLK2 →	+0.468	+0.229	.001	.002	3	7
HNSC	SNRPE →	+0.841	+0.173	.001	<.001	3	7
UCEC	UBE2Q1-AS1 →	+0.584	+0.152	<.001	<.001	3	7
OV	GAS5 →	+0.805	+0.209	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,755 associations by consensus.

CPSF6 vs RFC5 — LSCC

Explore this scatter interactively →