CPSF6

Across TCGA patient cohorts, CPSF6 mutation is significantly associated with the RNA expression of many other genes, with 2,287 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPSF6-associated genes across cancer lineages are MTCO1P49, RPS27P12, and CCL4. Each is linked with CPSF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CPSF6-to-partner and partner-to-CPSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO1P49 grouped by CPSF6-low versus CPSF6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF6→partner) and Y-score (partner→CPSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTCO1P49 →	+0.054	+4.705	.002	.003	3	3
CESC	RPS27P12 →	+0.224	+4.969	<.001	.004	3	2
UCEC	CCL4 →	+1.024	+2.828	<.001	<.001	3	2
BLCA	KRTAP10-4 →	+0.032	+5.177	.004	.007	3	2
COAD	MTCYBP45 →	+0.137	+4.734	<.001	.002	3	2
BLCA	IGHD1-1 →	+1.359	+4.973	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,287 associations by consensus.

MTCO1P49 by CPSF6 expression — CESC

Explore this box plot interactively →