CPSF6

Across TCGA cell cohorts, CPSF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,960 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CPSF6-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Mitotic DNA integrity checkpoint signaling, and Negative regulation of gene expression, epigenetic. Each is linked with CPSF6 in more than 19 cancer types. Because this analysis shows association rather than direction, both CPSF6-to-partner and partner-to-CPSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by CPSF6-low versus CPSF6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF6→partner) and Y-score (partner→CPSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.089	+0.968	<.001	.001	3	20
BONE	Mitotic DNA integrity checkpoint signaling →	+0.115	+0.920	.003	.002	3	20
BONE	Negative regulation of gene expression, epigenetic →	+0.084	+1.055	.001	<.001	3	20
BONE	RNA localization →	+0.099	+0.697	<.001	<.001	3	20
BONE	DNA replication checkpoint signaling →	+0.215	+0.929	.003	.002	3	20
BONE	Regulation of double-strand break repair via homologous recombination →	+0.125	+0.823	.001	.004	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,960 associations by consensus.

Epigenetic regulation of gene expression by CPSF6 expression — BONE

Explore this box plot interactively →