CPSF3

Across TCGA patient cohorts, CPSF3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPSF3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with CPSF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPSF3-to-partner and partner-to-CPSF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CPSF3-low versus CPSF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF3→partner) and Y-score (partner→CPSF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-2.087	.008	.005	3	1
UCEC	eIF4E →	+0.206	+3.247	.011	<.001	3	1
UCEC	eIF4G →	+0.325	+3.321	.006	.009	3	1
UCEC	ERK2 →	+0.186	+1.678	.011	.023	3	1
UCEC	FoxM1 →	+0.234	+1.678	.018	.023	3	1
UCEC	JNK_pT183_Y185 →	-0.160	-1.807	.013	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

EGFR_pY1068 by CPSF3 expression — UCEC

Explore this box plot interactively →