CPSF3

Across TCGA cell cohorts, CPSF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,485 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CPSF3-associated GO terms across cancer lineages are DNA-templated DNA replication, Mitotic sister chromatid cohesion, and DNA strand elongation. Each is linked with CPSF3 in more than 17 cancer types. Because this analysis shows association rather than direction, both CPSF3-to-partner and partner-to-CPSF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by CPSF3-low versus CPSF3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF3→partner) and Y-score (partner→CPSF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.164	+1.027	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid cohesion →	+0.127	+0.850	<.001	.003	3	17
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.204	+1.082	<.001	<.001	3	16
KIDNEY	mRNA 3'-end processing by stem-loop binding and cleavage →	+0.169	+0.752	<.001	<.001	3	16
OVARY	Nuclear histone mRNA catabolic process →	+0.109	+0.650	<.001	<.001	3	16
SOFT_TISSUE	Sister chromatid cohesion →	+0.119	+0.773	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,485 associations by consensus.

DNA-templated DNA replication by CPSF3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →