CPSF2

Across TCGA patient cohorts, CPSF2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPSF2-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and EGFR. Each is linked with CPSF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPSF2-to-partner and partner-to-CPSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CPSF2-low versus CPSF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF2→partner) and Y-score (partner→CPSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.204	+3.598	.003	.001	3	2
UCEC	EGFR_pY1068 →	-0.194	-2.584	.019	.010	3	1
UCEC	EGFR →	-0.114	-2.115	.030	.017	3	1
UCEC	A-Raf_pS299 →	-0.113	-1.906	.004	.015	3	1
UCEC	GATA3 →	-0.148	-1.658	.017	.021	3	1
UCEC	Heregulin →	-0.111	-2.687	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by CPSF2 expression — UCEC

Explore this box plot interactively →