CPSF1

Across TCGA pan-cancer cohorts, CPSF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CPSF1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CPSF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CPSF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where CPSF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.903	1.000	.004	61	view →
CCRCC	DFS	Median	All	0.714	0.882	.009	13	view →
PDAC	DFS	Tertile	All	0.296	0.521	.010	8	view →
LUAD	OS	Quartile	III,IV	0.993	0.427	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CPSF1–HNSC (DFS)

Open the HNSC breakdown →