CPSF1

Across TCGA patient cohorts, CPSF1 mutation is significantly associated with the RNA expression of many other genes, with 2,620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPSF1-associated genes across cancer lineages are MND1, RNA5SP162, and SKA1. Each is linked with CPSF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CPSF1-to-partner and partner-to-CPSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MND1 grouped by CPSF1-low versus CPSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF1→partner) and Y-score (partner→CPSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MND1 →	+0.578	+1.273	<.001	.008	3	4
BRCA	RNA5SP162 →	+0.681	+3.251	<.001	.007	3	3
UCEC	SKA1 →	+0.611	+2.684	<.001	<.001	3	3
UCEC	BOLA3 →	+0.266	+2.087	.008	.005	3	3
UCEC	SFXN1 →	+0.379	+1.606	<.001	.005	3	3
UCEC	FXN →	+0.388	+1.458	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,620 associations by consensus.

MND1 by CPSF1 expression — UCEC

Explore this box plot interactively →