CPSF1

Across TCGA patient cohorts, CPSF1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPSF1-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Ku80. Each is linked with CPSF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CPSF1-to-partner and partner-to-CPSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CPSF1-low versus CPSF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF1→partner) and Y-score (partner→CPSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.377	+1.882	.023	.031	3	5
UCEC	Caspase-7-cleavedD198 →	+0.788	+1.682	<.001	.006	3	4
UCEC	Ku80 →	+0.278	+1.657	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.738	+2.485	<.001	<.001	2	4
UCEC	ERK2 →	+0.188	+2.415	.001	.002	3	2
UCEC	IGFBP2 →	-0.438	-1.201	.029	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ASNS by CPSF1 expression — COAD

Explore this box plot interactively →