CPSF1

Across TCGA cell cohorts, CPSF1 mutation is significantly associated with the RNA expression of many other genes, with 783 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CPSF1-associated genes across cancer lineages are KRT28, MREG, and CENPM. Each is linked with CPSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPSF1-to-partner and partner-to-CPSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT28 grouped by CPSF1-low versus CPSF1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF1→partner) and Y-score (partner→CPSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRT28 →	+2.694	+3.999	.001	.004	3	2
BREAST	MREG →	+1.186	+3.220	.004	.005	3	2
BLOOD_Leukemia	CENPM →	+0.650	+3.115	.001	.009	3	2
BLOOD_Leukemia	CBY1 →	+0.474	+2.730	.003	.001	3	2
LARGE_INTESTINE	TRMU →	+0.560	+3.169	.001	.009	3	2
BLOOD_Leukemia	PARD6A →	+0.918	+3.442	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 783 associations by consensus.

KRT28 by CPSF1 expression — SOFT_TISSUE

Explore this box plot interactively →