CPS1

Across TCGA pan-cancer cohorts, CPS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CPS1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CPS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CPS1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where CPS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.598	0.904	<.001	73	view →
PDAC	OS	Median	All	0.470	0.265	<.001	33	view →
CCRCC	OS	Quartile	All	0.994	0.669	.001	30	view →
LSCC	OS	Median	III,IV	0.472	0.884	.013	15	view →
GBM	DFS	Median	All	0.781	0.580	.025	1	view →
HNSC	OS	Quartile	III,IV	0.798	0.501	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CPS1–LUAD (OS)

Open the LUAD breakdown →