CPS1

Across TCGA patient cohorts, CPS1 mutation is significantly associated with the RNA expression of many other genes, with 7,090 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPS1-associated genes across cancer lineages are TRIAP1, NDUFA12, and MNAT1. Each is linked with CPS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CPS1-to-partner and partner-to-CPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIAP1 grouped by CPS1-low versus CPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPS1→partner) and Y-score (partner→CPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIAP1 →	+0.428	+2.081	<.001	<.001	3	5
STAD	NDUFA12 →	+0.419	+3.509	.001	.002	3	5
UCEC	MNAT1 →	+0.389	+2.064	<.001	.001	3	5
UCEC	SLBP →	+0.623	+2.010	<.001	<.001	3	5
UCEC	BCCIP →	+0.401	+2.576	<.001	<.001	3	5
UCEC	ZWINT →	+0.804	+1.807	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,090 associations by consensus.

TRIAP1 by CPS1 expression — UCEC

Explore this box plot interactively →