CPS1

Across TCGA cell cohorts, CPS1 mutation is significantly associated with the RNA expression of many other genes, with 433 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPS1-associated genes across cancer lineages are GABARAPL1, GRAPL, and PRR20B. Each is linked with CPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPS1-to-partner and partner-to-CPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABARAPL1 grouped by CPS1-low versus CPS1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPS1→partner) and Y-score (partner→CPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GABARAPL1 →	+1.842	+3.459	.001	.002	3	2
LUNG_SCLC	GRAPL →	+0.313	+3.807	.001	<.001	3	2
LUNG_SCLC	PRR20B →	+0.020	+3.169	<.001	<.001	3	2
LUNG_SCLC	PRR20A →	+0.020	+3.169	<.001	<.001	3	2
LUNG_SCLC	PRR20D →	+0.020	+3.169	<.001	<.001	3	2
LUNG_SCLC	PRR20E →	+0.020	+3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 433 associations by consensus.

GABARAPL1 by CPS1 expression — LUNG_SCLC

Explore this box plot interactively →