CPPED1

Across TCGA patient cohorts, CPPED1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPPED1-associated genes across cancer lineages are ERK2, eIF4E, and FASN. Each is linked with CPPED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPPED1-to-partner and partner-to-CPPED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CPPED1-low versus CPPED1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPPED1→partner) and Y-score (partner→CPPED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.183	+2.999	.025	.035	3	2
UCEC	eIF4E →	+0.218	+2.222	.014	.011	3	1
UCEC	FASN →	+0.336	+1.700	.044	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.170	-2.321	.017	.034	3	1
UCEC	MSH2 →	-0.326	-3.143	<.001	.018	3	1
UCEC	Notch1 →	+0.176	+3.179	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ERK2 by CPPED1 expression — UCEC

Explore this box plot interactively →