CPOX

Across TCGA pan-cancer cohorts, CPOX mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CPOX data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CPOX mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CPOX expression acts as an unfavorable survival marker, although some lineages such as OV and LUAD show a favorable association.

PDAC, OV, and GBM are the cancer types where CPOX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.655	0.862	.016	15	view →
OV	DFS	Tertile	All	1.000	0.805	.038	8	view →
GBM	OS	Quartile	All	0.261	0.564	.005	8	view →
LUAD	OS	Median	All	0.992	0.595	.001	8	view →
CCRCC	OS	Quartile	All	0.776	0.938	.028	8	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.817	.022	4	view →
HNSC	DFS	Median	IV	0.924	1.000	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CPOX–PDAC (DFS)

Open the PDAC breakdown →