CPO

Across TCGA patient cohorts, CPO RNA expression is significantly associated with the protein abundance of many other proteins, with 11,655 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CPO-associated proteins across cancer lineages are DOT1L_S834, MAPRE3, and SCLY. Each is linked with CPO in more than 4 cancer types. Because this analysis shows association rather than direction, both CPO-to-partner and partner-to-CPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CPO versus DOT1L_S834 in BRCA, with a Pearson correlation of -0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CPO→partner) and Y-score (partner→CPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DOT1L_S834 →	-0.676	-0.671	<.001	<.001	3	5
BRCA	MAPRE3 →	+0.393	+0.577	<.001	.001	3	5
BRCA	SCLY →	+0.434	+0.691	<.001	<.001	3	4
BRCA	FBXO38 →	+0.497	+0.764	<.001	<.001	3	4
LUAD	FANCI →	-0.529	-0.325	<.001	.006	3	4
BRCA	NOP2 →	-0.455	-0.623	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,655 associations by consensus.

CPO vs DOT1L_S834 — BRCA

Explore this scatter interactively →