CPO

Across TCGA patient cohorts, CPO mutation is significantly associated with the RNA expression of many other genes, with 1,619 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPO-associated genes across cancer lineages are RNU7-20P, NPM1P17, and RN7SL811P. Each is linked with CPO in more than 1 cancer types. Because this analysis shows association rather than direction, both CPO-to-partner and partner-to-CPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-20P grouped by CPO-low versus CPO-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPO→partner) and Y-score (partner→CPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU7-20P →	+0.639	+5.306	.001	.006	3	2
LUAD	NPM1P17 →	+0.065	+4.575	<.001	.001	3	2
HNSC	RN7SL811P →	+0.145	+5.241	<.001	.007	3	2
UCEC	C16orf95 →	+0.343	+2.724	<.001	.003	3	2
HNSC	RNU6-1187P →	+0.435	+5.182	<.001	.007	3	2
CESC	KRTAP12-3 →	+0.107	+6.569	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,619 associations by consensus.

RNU7-20P by CPO expression — CESC

Explore this box plot interactively →