CPO

Across TCGA cell cohorts, CPO mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CPO-associated genes across cancer lineages are TEX33, DEFB132, and SPANXN4. Each is linked with CPO in more than 1 cancer types. Because this analysis shows association rather than direction, both CPO-to-partner and partner-to-CPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX33 grouped by CPO-low versus CPO-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPO→partner) and Y-score (partner→CPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TEX33 →	+0.036	+6.266	<.001	<.001	3	1
BLOOD_Lymphoma	DEFB132 →	+0.006	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	SPANXN4 →	+0.117	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CXorf51B →	+2.803	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TEX33 by CPO expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →