CPNE8

Across TCGA pan-cancer cohorts, CPNE8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CPNE8 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CPNE8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CPNE8 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where CPNE8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.289	0.772	.002	21	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	19	view →
LSCC	OS	Quartile	II,III,IV	0.401	0.858	.005	15	view →
PDAC	OS	Median	III,IV	0.641	0.856	.003	15	view →
OV	DFS	Median	All	1.000	0.765	.049	8	view →
CCRCC	DFS	Tertile	All	0.530	0.894	.004	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CPNE8–LUAD (OS)

Open the LUAD breakdown →