CPNE8

Across TCGA patient cohorts, CPNE8 mutation is significantly associated with the RNA expression of many other genes, with 1,884 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPNE8-associated genes across cancer lineages are IMP3P2, MIR3941, and TBC1D3C. Each is linked with CPNE8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CPNE8-to-partner and partner-to-CPNE8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP3P2 grouped by CPNE8-low versus CPNE8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE8→partner) and Y-score (partner→CPNE8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IMP3P2 →	+0.154	+1.504	<.001	.002	3	3
GBM	MIR3941 →	+0.491	+5.149	<.001	.007	3	2
GBM	TBC1D3C →	+0.018	+5.352	<.001	.005	3	2
LIHC	MIR6508 →	+0.658	+5.878	<.001	.002	3	2
CESC	RNU6-1191P →	+1.251	+5.103	<.001	.008	3	2
COAD	RN7SL134P →	+0.162	+3.374	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,884 associations by consensus.

IMP3P2 by CPNE8 expression — UCEC

Explore this box plot interactively →